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| So honored to be pictured here with the Molecular Genetics and Cardiac Regeneration Laboratory researchers. Dr. Mona Nemer is 6th from the right |
We met Dr. Mona Nemer initially through a phone call in December of 2016. As she described her work that day, at some point tears began to flow from my eyes. After searching for so long, someone was describing the BAV experience, in both individuals and families, just the way it happens, in my own family and so many others. Without minimizing, without trivializing, Dr. Nemer so fully described what I so painfully know to be true - the unpredictable and sometimes deadly experiences in BAV families.
Dr. Nemer is not a "people" doctor. She is a research scientist. And those individuals and families she talked about so movingly were not human beings, they were mice. Yes, mice families, but oh so much like my own! Families with bicuspid aortic valves and the other complications that can go with it.
I told my husband about these mice - about their two leaflet heart valves, their aortic aneurysms, their dissections, and their high blood pressure! We felt such a kinship to them. From that day onward, we had hope that these researchers would learn even more from these wonderful creatures, things that could help human families like ours and the many millions scattered around the world. It was a hope my husband remembered through out what became the last weeks and days of his life.
I dreamed of just spending a little time in this laboratory, meeting these talented researchers, and seeing these wonderful mice. In September, 2018, my dream came true! It was thrilling to walk into that very special laboratory at last - a place so focused on the challenges of BAV!
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| Dr. Lara Gharibeh and Dr. Alice Lau sit next to one another in the lab, such wonderful collaboration as they search for answers about BAV! |
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| So special for me to look through this microscope that they use to study BAV in mice hearts! |
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| Front left, Dr. Bernard Jasmin, Dean of the Faculty of Medicine, Front right, Dr. Mona Nemer Back far right, Dr. Daniel Figeys, Chair of Dept of Biochemistry, Microbiology, & Immunology The motto of the Medical School "We teach to heal" is on the wall in French and English |
This laboratory is located at the University of Ottawa, housed within the Department of Biochemistry, Microbiology, and Immunology within the Faculty of Medicine. We were warmly welcomed by the Dean of Medicine, Dr. Bernard Jasmin, along with others, spending time getting acquainted before a very special afternoon of research presentations by three members of the lab: Dr. Lara Gharibeh, Dr. Alice Lau, and Dr. Yuejuan Xu.
In September 2017, the Bicuspid Aortic Foundation provided a scholarship to Lara Gharibeh in support of her research on BAV. This is the paper that she published based on that work:
GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to R-L Type Bicuspid Aortic Valve The full paper is freely available at that link and speaks to the excellent, meticulous work done in this laboratory.
A few years ago, I wrote about BAV families being strangers, unrecognized and misunderstood, when they seek help. Bicuspid Aortic Valve Families - Strangers in Two Worlds? At long last, this first day and on the following days there in Ottawa, as a representative of BAV families, I was so warmly welcomed and understood by those who are working very diligently to understand and help us. It was a wonderful feeling, beyond description!! I have that warm glow with me still. I want to thank these researchers once again for what they are doing to help us.
Thank you for recognizing the challenge
and caring about those with BAV,
for seeking answers to the mysteries,
and in doing so,
Creating a Climate of Hope!
~Arlys Velebir
Bicuspid Aortic Foundation
